Cyclobarbital

Cyclobarbital
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	Oral (tablets)
ATC code	N05CA10 (WHO) ;
Legal status
Legal status	BR: Class B1 (Psychoactive drugs); CA: Schedule IV; DE: Anlage II (Authorized trade only, not prescriptible); UK: Class B; UN: Psychotropic Schedule III;
Pharmacokinetic data
Metabolism	Hepatic
Excretion	Renal
Identifiers
	IUPAC name 5-(1-cyclohexenyl)-5-ethyl-1,3-diazinane-2,4,6-trione;
CAS Number	52-31-3 ; calcium: 143-76-0 ;
PubChem CID	5838;
ChemSpider	5632 ;
UNII	0M8A98AD9H; calcium: 0HZN7FV25R ;
KEGG	D07323 ;
ChEMBL	ChEMBL268164 ;
CompTox Dashboard (EPA)	DTXSID9022865 ;
ECHA InfoCard	100.000.127
Chemical and physical data
Formula	C12H16N2O3
Molar mass	236.271 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1NC(=O)NC(=O)C1(/C2=C/CCCC2)CC;
	InChI InChI=1S/C12H16N2O3/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16/h6H,2-5,7H2,1H3,(H2,13,14,15,16,17) ; Key:WTYGAUXICFETTC-UHFFFAOYSA-N ;
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Cyclobarbital, also known as cyclobarbitol or cyclobarbitone, is a barbiturate derivative.^[2] It was available in Russia as a fixed-dose combination with diazepam (100 mg cyclobarbital + 10 mg diazepam; brand name Reladorm) for the treatment of insomnia but was discontinued in 2019.

References

^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ Breimer DD, Winten MA (March 1976). "Pharmacokinetics and relative bioavailability of cyclobarbital calcium in man after oral administration". European Journal of Clinical Pharmacology. 09 (5–6): 443–50. doi:10.1007/bf00606563. PMID 989475. S2CID 20271169.

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[1] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[2] Breimer DD, Winten MA (March 1976). "Pharmacokinetics and relative bioavailability of cyclobarbital calcium in man after oral administration". European Journal of Clinical Pharmacology. 09 (5–6): 443–50. doi:10.1007/bf00606563. PMID 989475. S2CID 20271169.

[2]

[1]

Clinical data


AHFS/Drugs.com	International Drug Names
Routes of administration	Oral (tablets)
ATC code	N05CA10 (WHO)
Legal status
Legal status	BR: Class B1 (Psychoactive drugs)^[1] CA: Schedule IV DE: Anlage II (Authorized trade only, not prescriptible) UK: Class B UN: Psychotropic Schedule III
Pharmacokinetic data
Metabolism	Hepatic
Excretion	Renal
Identifiers
IUPAC name 5-(1-cyclohexenyl)-5-ethyl-1,3-diazinane-2,4,6-trione
CAS Number	52-31-3^Y calcium: 143-76-0^Y
PubChem CID	5838
ChemSpider	5632^Y
UNII	0M8A98AD9H calcium: 0HZN7FV25R^Y
KEGG	D07323^N
ChEMBL	ChEMBL268164^Y
CompTox Dashboard (EPA)	DTXSID9022865
ECHA InfoCard	100.000.127
Chemical and physical data
Formula	C₁₂H₁₆N₂O₃
Molar mass	236.271 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C1NC(=O)NC(=O)C1(/C2=C/CCCC2)CC
InChI InChI=1S/C12H16N2O3/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16/h6H,2-5,7H2,1H3,(H2,13,14,15,16,17)^Y Key:WTYGAUXICFETTC-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)