ATF7

Cyclic AMP-dependent transcription factor ATF-7 is a protein that in humans is encoded by the ATF7 gene.

ATF7
Identifiers
Aliases	ATF7, ATFA, activating transcription factor 7
External IDs	OMIM: 606371; MGI: 2443472; HomoloGene: 4994; GeneCards: ATF7; OMA:ATF7 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.13 Start 53,507,856 bp End 53,626,410 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 F3 Start 102,434,381 bp End 102,533,899 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries gastric mucosa epithelium of colon Descending thoracic aorta minor salivary glands ascending aorta right coronary artery left coronary artery sural nerve Top expressed in neural layer of retina muscle of thigh yolk sac lip zygote aortic valve genital tubercle ascending aorta granulocyte tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity RNA polymerase II cis-regulatory region sequence-specific DNA binding enzyme binding DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific transcription factor binding protein binding metal ion binding mitogen-activated protein kinase binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nuclear periphery nucleus nucleoplasm Biological process viral process regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11016 223922 Ensembl ENSG00000170653 ENSMUSG00000099083 UniProt P17544 Q8R0S1 RefSeq (mRNA) NM_001130059 NM_001130060 NM_001206682 NM_001206683 NM_006856 NM_001366555 NM_001366556 NM_001366558 NM_001366561 NM_001366562 NM_001366563 NM_146065 NM_001310066 NM_001310067 NM_001310070 RefSeq (protein) NP_001123532 NP_001193611 NP_001193612 NP_006847 NP_001353484 NP_001353485 NP_001353487 NP_001353490 NP_001353491 NP_001353492 NP_001296995 NP_001296996 NP_001296999 Location (UCSC) Chr 12: 53.51 – 53.63 Mb Chr 15: 102.43 – 102.53 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Homonym

In 2001, Peters et al. published a paper showing that ATF-7, a Novel bZIP Protein, interacts with PTP4A1. This ATF-7 is actually ATF5 and not ATF7, as noted by the authors at the end of their paper ("Note Added in Proof—While this manuscript was under review, sequences for mouse and human ATF-5 were deposited in GenBankTM. It appears that ATF-7 and ATF-5 are likely to be the same protein. In addition, an unrelated sequence named ATF7 has also been deposited in GenBankTM. In order to avoid confusion, future work on the protein described in this publication will likely refer to it as either ATF-5 or ATF-5/7.")

Further reading

• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
• Hamard PJ, Dalbies-Tran R, Hauss C, Davidson I, Kedinger C, Chatton B (2005). "A functional interaction between ATF7 and TAF12 that is modulated by TAF4". Oncogene. 24 (21): 3472–83. doi:10.1038/sj.onc.1208565. PMID 15735663. S2CID 23431610.
• Hamard PJ, Boyer-Guittaut M, Camuzeaux B, Dujardin D, Hauss C, Oelgeschläger T, Vigneron M, Kedinger C, Chatton B (2007). "Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity". Nucleic Acids Res. 35 (4): 1134–44. doi:10.1093/nar/gkl1168. PMC 1851647. PMID 17264123.
• Breitwieser W, Lyons S, Flenniken AM, Ashton G, Bruder G, Willington M, Lacaud G, Kouskoff V, Jones N (2007). "Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells". Genes Dev. 21 (16): 2069–82. doi:10.1101/gad.430207. PMC 1948861. PMID 17699753.
• Newman JR, Keating AE (2003). "Comprehensive identification of human bZIP interactions with coiled-coil arrays". Science. 300 (5628): 2097–101. Bibcode:2003Sci...300.2097N. doi:10.1126/science.1084648. PMID 12805554. S2CID 36715183.
• Newman SP, Bates NP, Vernimmen D, Parker MG, Hurst HC (2000). "Cofactor competition between the ligand-bound oestrogen receptor and an intron 1 enhancer leads to oestrogen repression of ERBB2 expression in breast cancer". Oncogene. 19 (4): 490–7. doi:10.1038/sj.onc.1203416. PMID 10698518. S2CID 7619430.
• Goetz J, Chatton B, Mattei MG, Kedinger C (1997). "Structure and expression of the ATFa gene". J. Biol. Chem. 271 (47): 29589–98. doi:10.1074/jbc.271.47.29589. PMID 8939888.
• Bocco JL, Bahr A, Goetz J, Hauss C, Kallunki T, Kedinger C, Chatton B (1996). "In vivo association of ATFa with JNK/SAP kinase activities". Oncogene. 12 (9): 1971–80. PMID 8649858.
• Pescini R, Kaszubska W, Whelan J, DeLamarter JF, Hooft van Huijsduijnen R (1994). "ATF-a0, a novel variant of the ATF/CREB transcription factor family, forms a dominant transcription inhibitor in ATF-a heterodimers". J. Biol. Chem. 269 (2): 1159–65. doi:10.1016/S0021-9258(17)42236-8. PMID 8288576.
• Zhou Q, Gedrich RW, Engel DA (1995). "Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB". J. Virol. 69 (7): 4323–30. doi:10.1128/JVI.69.7.4323-4330.1995. PMC 189172. PMID 7769693.

External links

• ATF7+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human ATF7 genome location and ATF7 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.