SALL2

Sal-like protein 2 is a protein that in humans is encoded by the SALL2 gene.

SALL2
Identifiers
Aliases	SALL2, COLB, HSAL2, Sal-2, ZNF795, p150(Sal2), spalt-like transcription factor 2, spalt like transcription factor 2
External IDs	OMIM: 602219; MGI: 1354373; HomoloGene: 9269; GeneCards: SALL2; OMA:SALL2 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q11.2 Start 21,521,080 bp End 21,537,216 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 C2 Start 52,548,629 bp End 52,566,219 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis superior vestibular nucleus paraflocculus of cerebellum ventral tegmental area ventricular zone inferior olivary nucleus right hemisphere of cerebellum dorsal motor nucleus of vagus nerve pons oocyte Top expressed in vestibular sensory epithelium otic vesicle saccule dorsomedial hypothalamic nucleus otic placode median eminence supraoptic nucleus inferior colliculi habenula arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity sequence-specific DNA binding DNA binding protein binding metal ion binding nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific protein-containing complex binding Cellular component NuRD complex nucleus Biological process eye development negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II neural tube development signal transduction transcription, DNA-templated positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6297 50524 Ensembl ENSG00000165821 ENSMUSG00000049532 UniProt Q9Y467 Q9QX96 RefSeq (mRNA) NM_001291446 NM_001291447 NM_005407 NM_001364564 NM_001244916 NM_015772 RefSeq (protein) NP_001278375 NP_001278376 NP_005398 NP_001351493 NP_001231845 NP_056587 Location (UCSC) Chr 14: 21.52 – 21.54 Mb Chr 14: 52.55 – 52.57 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Sweetman D, Münsterberg A (May 2006). "The vertebrate spalt genes in development and disease" (PDF). Developmental Biology. 293 (2): 285–93. doi:10.1016/j.ydbio.2006.02.009. PMID 16545361. S2CID 45268563.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (April 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
• Nielsen TO, Hsu FD, O'Connell JX, Gilks CB, Sorensen PH, Linn S, West RB, Liu CL, Botstein D, Brown PO, van de Rijn M (October 2003). "Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology". The American Journal of Pathology. 163 (4): 1449–56. doi:10.1016/S0002-9440(10)63502-X. PMC 1868308. PMID 14507652.
• Li D, Tian Y, Ma Y, Benjamin T (May 2004). "p150(Sal2) is a p53-independent regulator of p21(WAF1/CIP)". Molecular and Cellular Biology. 24 (9): 3885–93. doi:10.1128/MCB.24.9.3885-3893.2004. PMC 387742. PMID 15082782.