MNDA

This article is about the protein in humans. For the MND Association, see Motor Neurone Disease Association.

Myeloid cell Nuclear Differentiation Antigen is a protein that in humans is encoded as MNDA gene.

MNDA
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2DBG
Identifiers
Aliases	MNDA, PYHIN3, myeloid cell nuclear differentiation antigen
External IDs	OMIM: 159553; HomoloGene: 74438; GeneCards: MNDA; OMA:MNDA - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q23.1 Start 158,831,351 bp End 158,849,506 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte trabecular bone blood granulocyte bone marrow periodontal fiber germinal epithelium bone marrow cells spleen palpebral conjunctiva n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein binding double-stranded DNA binding Cellular component cytoplasm extracellular exosome nucleus extracellular region nucleoplasm nucleolus azurophil granule lumen ficolin-1-rich granule lumen Biological process B cell receptor signaling pathway cellular defense response regulation of transcription, DNA-templated negative regulation of B cell proliferation transcription, DNA-templated cellular response to DNA damage stimulus positive regulation of apoptotic process neutrophil degranulation activation of innate immune response cellular response to interferon-beta positive regulation of interleukin-1 beta production Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4332 n/a Ensembl ENSG00000163563 n/a UniProt P41218 n/a RefSeq (mRNA) NM_002432 n/a RefSeq (protein) NP_002423 n/a Location (UCSC) Chr 1: 158.83 – 158.85 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Function

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5' UTR, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.

Further reading

• Burrus GR, Briggs JA, Briggs RC (February 1992). "Characterization of the human myeloid cell nuclear differentiation antigen: relationship to interferon-inducible proteins". Journal of Cellular Biochemistry. 48 (2): 190–202. doi:10.1002/jcb.240480210. PMID 1377701. S2CID 25290353.
• Ott J, Fràter-Schröder M (1982). "Absence of linkage between transcobalamin II and ABO". Human Genetics. 59 (2): 164–5. doi:10.1007/BF00293068. PMID 7327575. S2CID 33911295.
• Dawson MJ, Trapani JA, Briggs RC, Nicholl JK, Sutherland GR, Baker E (1995). "The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression". Immunogenetics. 41 (1): 40–3. doi:10.1007/BF00188431. PMID 7806273. S2CID 12788123.
• Briggs R, Dworkin L, Briggs J, Dessypris E, Stein J, Stein G, Lian J (February 1994). "Interferon alpha selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage". Journal of Cellular Biochemistry. 54 (2): 198–206. doi:10.1002/jcb.240540208. PMID 8175894. S2CID 37002803.
• Xie J, Briggs JA, Briggs RC (September 1998). "Human hematopoietic cell specific nuclear protein MNDA interacts with the multifunctional transcription factor YY1 and stimulates YY1 DNA binding". Journal of Cellular Biochemistry. 70 (4): 489–506. doi:10.1002/(SICI)1097-4644(19980915)70:4<489::AID-JCB6>3.0.CO;2-F. PMID 9712147. S2CID 42226327.
• Doggett KL, Briggs JA, Linton MF, Fazio S, Head DR, Xie J, Hashimoto Y, Laborda J, Briggs RC (2002). "Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulates Dlk1 expression". Journal of Cellular Biochemistry. 86 (1): 56–66. doi:10.1002/jcb.10190. PMID 12112016. S2CID 30240885.
• Fukushi M, Higuchi M, Oie M, Tetsuka T, Kasolo F, Ichiyama K, Yamamoto N, Katano H, Sata T, Fujii M (December 2003). "Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with human myeloid cell nuclear differentiation antigen induced by interferon alpha". Virus Genes. 27 (3): 237–47. doi:10.1023/A:1026391715071. PMID 14618084. S2CID 1868558.
• Briggs RC, Atkinson JB, Miranda RN (May 2005). "Variable expression of human myeloid specific nuclear antigen MNDA in monocyte lineage cells in atherosclerosis". Journal of Cellular Biochemistry. 95 (2): 293–301. doi:10.1002/jcb.20435. PMID 15778972. S2CID 39863400.
• Asefa B, Dermott JM, Kaldis P, Stefanisko K, Garfinkel DJ, Keller JR (February 2006). "p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation". FEBS Letters. 580 (5): 1205–14. doi:10.1016/j.febslet.2006.01.032. PMID 16458891. S2CID 21158774.
• Briggs RC, Shults KE, Flye LA, McClintock-Treep SA, Jagasia MH, Goodman SA, Boulos FI, Jacobberger JW, Stelzer GT, Head DR (May 2006). "Dysregulated human myeloid nuclear differentiation antigen expression in myelodysplastic syndromes: evidence for a role in apoptosis" (PDF). Cancer Research. 66 (9): 4645–51. doi:10.1158/0008-5472.CAN-06-0229. PMID 16651415.

External links

• MNDA+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.